Measurements of gene expression or signal transduction activity are conventionally
performed using methods that require either the destruction or live imaging of a biological …

Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo
representations that explore a much larger space of possible forms, or morphospace …

Gastrulation is a key milestone in the development of an organism. It is a period of cell
proliferation and coordinated cellular rearrangement, that creates an outline of the body …

Gastruloids are a powerful in vitro model of early human development. However, although
elongated and composed of all three germ layers, human gastruloids do not morphologically …

Aggregates of stem cells can break symmetry and self-organize into embryo-like structures
with complex morphologies and gene expression patterns. Mechanisms including reaction …

Gene expression is orchestrated by transcription factors, which function within the context of
a three-dimensional genome. Zinc-finger protein 143 (ZNF143/ZFP143) is a transcription …

Primordial germ cells (PGCs) are the early embryonic precursors of gametes–sperm and
egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells …

In embryonic stem cell (ESC) models for early development, spatially and temporally varying
patterns of signaling and cell types emerge spontaneously. However, mechanistic insight …

During neural tube (NT) development, the notochord induces an organizer, the floorplate,
which secretes Sonic Hedgehog (SHH) to pattern neural progenitors. Conversely, NT …

Mammalian stem-cell-based models of embryo development (stembryos) hold great promise
in basic and applied research. However, considerable phenotypic variation despite identical …