Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

ADP is an important platelet agonist causing shape change from smooth discoid shape to
spiculated spheres and platelet aggregation. However, the molecular mechanisms involved …

Abstract P2Y receptors are G protein‐coupled receptors (GPCRs) that are activated by
adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y …

Snake envenomation employs three well integrated strategies: prey immobilization via
hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine …

Nucleotides such as ATP, ADP, UTP or the diadenosine polyphosphates and possibly even
NAD+ are extracellular signaling substances in the brain and in other tissues. Enzymes …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

We report the discovery, tissue distribution and pharmacological characterization of a novel
receptor, which we have named H4. Like the three histamine receptors reported previously …