Programmed cell death in asthma: apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis

L Liu, L Zhou, LL Wang, PD Zheng… - Journal of …, 2023 - Taylor & Francis
Bronchial asthma is a complex heterogeneous airway disease, which has emerged as a
global health issue. A comprehensive understanding of the different molecular mechanisms …

The role of respiratory flora in the pathogenesis of chronic respiratory diseases

MY Guo, HK Chen, HZ Ying, FS Qiu… - BioMed Research …, 2021 - Wiley Online Library
Large quantities of bacteria, including Firmicutes, Actinobacteria, and Bacteroidetes,
colonize the surface of the respiratory mucosa of healthy people. They interact and coexist …

Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary …

C Yang, L Rubin, X Yu, P Lazarovici… - Medicinal Research …, 2024 - Wiley Online Library
Abstract Adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK) is a highly
conserved eukaryotic enzyme discovered as a key regulator of cellular energy homeostasis …

Long-chain non-coding RNA n337374 relieves symptoms of respiratory syncytial virus-induced asthma by inhibiting dendritic cell maturation via the CD86 and the …

S Sun, M Yao, L Yuan, J Qiao - Allergologia et Immunopathologia, 2021 - all-imm.com
Background: In this study, we investigated the relationship between long-chain non-coding
RNAs (lncRNAs) and respiratory syncytial virus (RSV)-exacerbated asthma. Methods …

[HTML][HTML] Autophagy-related genes are involved in the progression and prognosis of asthma and regulate the immune microenvironment

F Yang, J Kong, Y Zong, Z Li, M Lyu, W Li, W Li… - Frontiers in …, 2022 - frontiersin.org
Background Autophagy has been proven to play an important role in the pathogenesis of
asthma and the regulation of the airway epithelial immune microenvironment. However, a …

Conciliatory Anti‐Allergic Decoction Attenuates Pyroptosis in RSV‐Infected Asthmatic Mice and Lipopolysaccharide (LPS)‐Induced 16HBE Cells by Inhibiting TLR3 …

Y Chen, Y Zhou, Q Wang, J Chen… - Journal of …, 2022 - Wiley Online Library
Respiratory syncytial virus (RSV) infection can deteriorate asthma by inducing persistent
airway inflammation. Increasing evidence elucidated that pyroptosis plays a pivotal role in …

[HTML][HTML] The multifaceted roles of autophagy in infectious, obstructive, and malignant airway diseases

M Carinci, L Palumbo, G Pellielo, ED Agyapong… - Biomedicines, 2022 - mdpi.com
Autophagy is a highly conserved dynamic process by which cells deliver their contents to
lysosomes for degradation, thus ensuring cell homeostasis. In response to environmental …

Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways

T Chen, S Bao, J Chen, J Zhang, H Wei, X Hu… - Pharmaceutical …, 2023 - Taylor & Francis
Context Xiaojianzhong decoction (XJZD), classically prescribed in Chinese medicine, has
protective and healing effects on gastric mucosal injury. However, the exact mechanism …

[HTML][HTML] New insights into autophagy in inflammatory subtypes of asthma

H Dong, W Yang, W Li, S Zhu, L Zhu, P Gao… - Frontiers in …, 2023 - frontiersin.org
Asthma is a heterogeneous airway disease characterized by airway inflammation and
hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular …

[HTML][HTML] Effects of WuHuTang on the function and autophagy of dendritic cells treated with exosomes induced by RSV

J Liu, B Yao, Y Luo, Z Zhou, X Ma, Y Ding… - Journal of …, 2024 - Elsevier
ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE WuHuTang (WHT) is a traditional
Chinese medicine compound for treating asthma, and the evidence supports that it has a …