[HTML][HTML] Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

A Doustmihan, M Fathi, MA Mazloomi, A Salemi… - Journal of Controlled …, 2023 - Elsevier
There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …

[HTML][HTML] Application of aptamer-drug delivery system in the therapy of breast cancer

R Fan, X Tao, X Zhai, Y Zhu, Y Li, Y Chen… - Biomedicine & …, 2023 - Elsevier
Despite significant treatment advances, breast cancer remains the leading cause of cancer
death in women. From the current treatment situation, in addition to developing …

Optimizing cisplatin delivery to triple-negative breast cancer through novel EGFR aptamer-conjugated polymeric nanovectors

L Agnello, S Tortorella, A d'Argenio, C Carbone… - Journal of Experimental …, 2021 - Springer
Background Management of triple-negative breast cancer (TNBC) is still challenging
because of its aggressive clinical behavior and limited targeted treatment options. Cisplatin …

Breast cancer: from pathophysiology to novel therapeutic approaches 2.0

A Zannetti - International Journal of Molecular Sciences, 2023 - mdpi.com
Breast cancer (BC) is the most common malignancy in women worldwide. It is a very
heterogeneous disease characterized by different molecular profiles that are clinically …

Aptamer-functionalized nanoparticles mediate PD-L1 siRNA delivery for effective gene silencing in triple-negative breast cancer cells

S Camorani, S Tortorella, L Agnello, C Spanu… - Pharmaceutics, 2022 - mdpi.com
Small interfering RNA (siRNA) therapies require effective delivery vehicles capable of
carrying the siRNA cargo into target cells. To achieve tumor-targeting, a drug delivery …

Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer

S Camorani, M Passariello, L Agnello… - Journal of Experimental …, 2020 - Springer
Background Triple-negative breast cancer (TNBC) is a uniquely aggressive cancer with high
rates of relapse due to resistance to chemotherapy. TNBC expresses higher levels of …

Selective photo-assisted eradication of Triple-Negative breast cancer cells through aptamer decoration of doped conjugated polymer nanoparticles

LE Ibarra, S Camorani, L Agnello, E Pedone, L Pirone… - Pharmaceutics, 2022 - mdpi.com
Photodynamic therapy (PDT) may be an excellent alternative in the treatment of breast
cancer, mainly for the most aggressive type with limited targeted therapies such as triple …

Profiling cancer cells by cell-SELEX: use of aptamers for discovery of actionable biomarkers and therapeutic applications thereof

S Shigdar, L Agnello, M Fedele, S Camorani, L Cerchia - Pharmaceutics, 2021 - mdpi.com
The identification of tumor cell-specific surface markers is a key step towards personalized
cancer medicine, allowing early assessment and accurate diagnosis, and development of …

Tissue Inhibitor of Metalloproteinases-1 Overexpression Mediates Chemoresistance in Triple-Negative Breast Cancer Cells

L Agnello, A d'Argenio, A Caliendo, R Nilo, A Zannetti… - Cells, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is among the most aggressive breast cancer subtypes.
Despite being initially responsive to chemotherapy, patients develop drug-resistant and …

Selection of a novel cell-internalizing RNA aptamer specific for CD22 antigen in B cell acute lymphoblastic leukemia

D Ruiz-Ciancio, LH Lin, S Veeramani… - … Therapy-Nucleic Acids, 2023 - cell.com
Despite improvements in B cell acute lymphoblastic leukemia (B-ALL) treatment, a
significant number of patients experience relapse of the disease, resulting in poor prognosis …