More than 50 years have passed since Kawasaki disease (KD) was first reported. 1
According to a nationwide survey, the number of patients with KD who became adults was …

Stroke is relatively rare in children, but can lead to significant morbidity and mortality.
Understanding that children with strokes present differently than adults and often present …

Background Neonates and children differ from adults in physiology, pharmacologic
responses to drugs, epidemiology, and long-term consequences of thrombosis. This …

Thrombosis has long been recognized as a potentially lifethreatening complication in
children with congenital heart disease (CHD), children with acquired heart disease, and in …

Unpublished and misreported studies make it difficult to determine the true value of a
treatment. Peter Doshi and colleagues call for sponsors and investigators of abandoned …

Background Sickle cell anemia is an inherited blood disorder that is characterized by painful
vaso-occlusive crises, for which there are few treatment options. Platelets mediate …

Among children, newborn infants are most vulnerable to development of thrombosis and
serious thromboembolic complications. Amongst newborns, those neonates who are …

P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …

OBJECTIVE: To determine the incidence, risk factors, and outcomes after early, unplanned
intervention on systemic-to-pulmonary artery shunts in neonates. METHODS: We …

The advent of digital, electronic, and molecular technologies has allowed the study of
complete genomes. Integrating this information into drug development has opened the door …