Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Nonalcoholic fatty liver disease 2020: the state of the disease

TG Cotter, M Rinella - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, with a worldwide
prevalence of 25%. In the United States, NAFLD and its subtype, nonalcoholic …

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

M Chen, L Wei, CT Law, FHC Tsang, J Shen… - Hepatology, 2018 - journals.lww.com
Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional
epigenetic studies have predominantly focused on DNA methylation, histone modifications …

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

M Eslam, J George - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

E Buzzetti, M Pinzani, EA Tsochatzis - Metabolism, 2016 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …

NAFLD in children: new genes, new diagnostic modalities and new drugs

V Nobili, A Alisi, L Valenti, L Miele… - Nature reviews …, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has rapidly become the most common form of
chronic liver disease in children and adolescents. Over the past 5 years, developments have …

Geographical similarity and differences in the burden and genetic predisposition of NAFLD

TCF Yip, E Vilar‐Gomez, S Petta, Y Yilmaz… - Hepatology, 2023 - journals.lww.com
NAFLD has become a major public health problem for more than 2 decades with a growing
prevalence in parallel with the epidemic of obesity and type 2 diabetes (T2D). The disease …

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

H Yki-Järvinen - The lancet Diabetes & endocrinology, 2014 - thelancet.com
Metabolic syndrome is a cluster of metabolic abnormalities that identifies people at risk of
diabetes and cardiovascular disease, whereas non-alcoholic fatty liver disease (NAFLD) is …

Nonalcoholic fatty liver disease: pathogenesis and disease spectrum

T Hardy, F Oakley, QM Anstee… - Annual review of …, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …

Cardiovascular risk in non-alcoholic fatty liver disease: mechanisms and therapeutic implications

C Tana, S Ballestri, F Ricci, A Di Vincenzo… - International journal of …, 2019 - mdpi.com
New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong
multifaceted relationship with diabetes and metabolic syndrome, and is associated with …