The intracellular signal transduction pathway by which the yeast Saccharomyces cerevisiae
responds to the presence of peptide mating pheromone in its surroundings is one of the best …

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for
generating cell diversity during development. The budding yeast Saccharomyces cerevisiae …

The Rho GTPases are implicated in almost every fundamental cellular process. They act as
molecular switches that cycle between an active GTP‐bound and an inactive GDP‐bound …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Complex biochemical networks can be understood by identifying their principal regulatory
motifs and mode of action. We model the early phase of budding yeast cellular polarization …

Cytokinesis is a temporally and spatially regulated process through which the cellular
constituents of the mother cell are partitioned into two daughter cells, permitting an increase …

Septins are conserved GTP-binding proteins that assemble into hetero-oligomeric
complexes and higher-order structures such as filaments, rings, hourglasses or gauzes …

Cell polarization generally occurs along a single well-defined axis that is frequently
determined by environmental cues such as chemoattractant gradients or cell–cell contacts …

The septins are a conserved family of GTP-binding, filament-forming proteins. In the yeast
Saccharomyces cerevisiae, the septins form a ring at the mother-bud neck that appears to …

Signaling molecules such as Cdc42 and mitogen-activated protein kinases (MAPKs) can
function in multiple pathways in the same cell. Here, we propose one mechanism by which …