[HTML][HTML] An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds
O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …
properties and hence have major pharmaceutical significance. They have an exceptional …
[HTML][HTML] Recent advances in the synthesis of bioactive glycohybrids via click-chemistry
Carbohydrates, traditionally known for their energy-providing role, have gained significant
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …
[HTML][HTML] Salicylic acid derivatives as potential α-glucosidase inhibitors: drug design, molecular docking and pharmacokinetic studies
Background Diabetes mellitus (DM) is one of the most defying health risk in the twenty-first
century promoting a high rate of morbidity and mortality that could possibly increase if no …
century promoting a high rate of morbidity and mortality that could possibly increase if no …
Bone marrow stem cell-derived β-cells: New issue for diabetes cell therapy
HA Aglan, SE Kotob, NS Mahmoud, MS Kishta… - Tissue and Cell, 2024 - Elsevier
This investigation aimed to establish the promising role of insulin-producing cells (IPCs)
growing from bone marrow-mesenchymal stem cells (BM-MSCs) in relieving hyperglycemia …
growing from bone marrow-mesenchymal stem cells (BM-MSCs) in relieving hyperglycemia …
Novel Hybrid Triazoline-Triazole Glycosides: Synthesis, Characterization, Antimicrobial Activity study via In Vitro, and In Silico Means
M ALSaeedy, ALA Arwa, A Alrabie, I Al-Qadsy… - Carbohydrate …, 2023 - Elsevier
Abstract Series of novel 1, 2, 3-triazole, and 1, 2, 3-triazoline glycosides (ae) were efficiently
synthesized starting from d-arabinose in an effort to synthesize a new type of hybrid …
synthesized starting from d-arabinose in an effort to synthesize a new type of hybrid …
Recent developments on the synthesis of biologically active glycohybrids
The exploration of hybridization emerges as a potent tool in advancing drug discovery
research, with a significant emphasis on carbohydrate-containing hybrid scaffolds. Evidence …
research, with a significant emphasis on carbohydrate-containing hybrid scaffolds. Evidence …
[HTML][HTML] Three new acrylic acid derivatives from Achillea mellifolium as potential inhibitors of Urease from Jack bean and α-Glucosidase from Saccharomyces …
(1) Background: Achillea mellifolium belongs to a highly reputed family of medicinal plants,
with plant extract being used as medicine in indigenous system. However, limited data is …
with plant extract being used as medicine in indigenous system. However, limited data is …
[HTML][HTML] Integrative Approach for Designing Novel Triazole Derivatives as α-Glucosidase Inhibitors: QSAR, Molecular Docking, ADMET, and Molecular Dynamics …
In response to the increasing prevalence of diabetes mellitus and the limitations associated
with the current treatments, there is a growing need to develop novel medications for this …
with the current treatments, there is a growing need to develop novel medications for this …