Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Fast and scalable ensemble learning method for versatile polygenic risk prediction
Polygenic risk scores (PRS) enhance population risk stratification and advance
personalized medicine, but existing methods face several limitations, encompassing issues …
personalized medicine, but existing methods face several limitations, encompassing issues …
[HTML][HTML] Biobank-scale methods and projections for sparse polygenic prediction from machine learning
In this paper we characterize the performance of linear models trained via widely-used
sparse machine learning algorithms. We build polygenic scores and examine performance …
sparse machine learning algorithms. We build polygenic scores and examine performance …
Ensembled best subset selection using summary statistics for polygenic risk prediction
Polygenic risk scores (PRS) enhance population risk stratification and advance
personalized medicine, yet existing methods face a tradeoff between predictive power and …
personalized medicine, yet existing methods face a tradeoff between predictive power and …
Genomic Insights for Personalized Care: Motivating At-Risk Individuals Toward Evidence-Based Health Practices
Background Lung cancer and tobacco use pose significant global health challenges,
necessitating a comprehensive translational roadmap for improved prevention strategies …
necessitating a comprehensive translational roadmap for improved prevention strategies …
Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers
B Blechter, X Wang, J Shi, K Shiraishi, J Choi… - medRxiv, 2024 - medrxiv.org
Background Lung adenocarcinoma (LUAD) among never-smokers is a public health burden
especially prevalent in East Asian (EAS) women. Polygenic risk scores (PRSs), which …
especially prevalent in East Asian (EAS) women. Polygenic risk scores (PRSs), which …
[HTML][HTML] Leveraging genetic correlations and multiple populations to improve genetic risk prediction for non-European populations
The disparity in genetic risk prediction accuracy between European and non-European
individuals highlights a critical challenge in health inequality. To bridge this gap, we …
individuals highlights a critical challenge in health inequality. To bridge this gap, we …
Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomes
Z Huang - medRxiv, 2024 - medrxiv.org
Type 2 Diabetes Mellitus (T2DM) is increasingly prevalent and significantly impacts patients'
lives. However, the phenotypic and genetic heterogeneity of the preclinical stage of T2DM …
lives. However, the phenotypic and genetic heterogeneity of the preclinical stage of T2DM …