G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …

The DNAs encoding the receptors that respond to the peptide mating pheromones of the
budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first …

Plasma membrane lipid composition must be maintained during growth and under
environmental insult. In yeast, signaling mediated by TOR Complex 2 (TORC2)-dependent …

The regulation of nutrient uptake into cells is important, as it allows to either increase
biomass for cell growth or to preserve homoeostasis. A key strategy to adjust cellular nutrient …

Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and
delivery to the lysosome in response to various stimuli. We report here that two amino acid …

Biological processes are dynamically regulated by signaling networks composed of protein
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …

Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug
classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was …

Substrate-transport–elicited endocytosis is a common control mechanism of membrane
transporters avoiding excess uptake of external compounds, though poorly understood at …

The adenosine monophosphate-activated protein kinase (AMPK) plays a central role in the
regulation of cellular metabolism. Recent studies reveal a novel role for AMPK in the …

To grow, eukaryotic cells must expand by inserting glycerolipids, sphingolipids, sterols, and
proteins into their plasma membrane, and maintain the proper levels and bilayer distribution …