Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
Heterotrimeric G protein-coupled receptor signaling in yeast mating pheromone response
CG Alvaro, J Thorner - Journal of Biological Chemistry, 2016 - ASBMB
The DNAs encoding the receptors that respond to the peptide mating pheromones of the
budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first …
budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first …
TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids
A Muir, S Ramachandran, FM Roelants, G Timmons… - Elife, 2014 - elifesciences.org
Plasma membrane lipid composition must be maintained during growth and under
environmental insult. In yeast, signaling mediated by TOR Complex 2 (TORC2)-dependent …
environmental insult. In yeast, signaling mediated by TOR Complex 2 (TORC2)-dependent …
The α‐arrestin family of ubiquitin ligase adaptors links metabolism with selective endocytosis
The regulation of nutrient uptake into cells is important, as it allows to either increase
biomass for cell growth or to preserve homoeostasis. A key strategy to adjust cellular nutrient …
biomass for cell growth or to preserve homoeostasis. A key strategy to adjust cellular nutrient …
Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases
K Ghaddar, A Merhi, E Saliba… - … and cellular biology, 2014 - Am Soc Microbiol
Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and
delivery to the lysosome in response to various stimuli. We report here that two amino acid …
delivery to the lysosome in response to various stimuli. We report here that two amino acid …
Identifying new substrates and functions for an old enzyme: calcineurin
J Roy, MS Cyert - Cold Spring Harbor Perspectives in …, 2020 - cshperspectives.cshlp.org
Biological processes are dynamically regulated by signaling networks composed of protein
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …
Developing novel antifungals: lessons from G protein-coupled receptors
V Velazhahan, BL McCann, E Bignell… - Trends in pharmacological …, 2023 - cell.com
Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug
classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was …
classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was …
Transition of yeast Can1 transporter to the inward-facing state unveils an α-arrestin target sequence promoting its ubiquitylation and endocytosis
Substrate-transport–elicited endocytosis is a common control mechanism of membrane
transporters avoiding excess uptake of external compounds, though poorly understood at …
transporters avoiding excess uptake of external compounds, though poorly understood at …
AMPK-mediated regulation of alpha-arrestins and protein trafficking
AF O'Donnell, MC Schmidt - International journal of molecular sciences, 2019 - mdpi.com
The adenosine monophosphate-activated protein kinase (AMPK) plays a central role in the
regulation of cellular metabolism. Recent studies reveal a novel role for AMPK in the …
regulation of cellular metabolism. Recent studies reveal a novel role for AMPK in the …
The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae
FM Roelants, KL Leskoske, MN Martinez Marshall… - Biomolecules, 2017 - mdpi.com
To grow, eukaryotic cells must expand by inserting glycerolipids, sphingolipids, sterols, and
proteins into their plasma membrane, and maintain the proper levels and bilayer distribution …
proteins into their plasma membrane, and maintain the proper levels and bilayer distribution …