The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Background models projecting future disease burden have focussed on one or two
diseases. Little is known on how risk factors of younger cohorts will play out in the future …

Central nervous system (CNS) disorders especially neurodegenerative disorders are the
major challenge for public health and demand the great attention of researchers to protect …

Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

Background Recent estimates suggesting that over half of Alzheimer's disease burden
worldwide might be attributed to potentially modifiable risk factors do not take into account …

Despite the significant public health issue that it poses, only five medical treatments have
been approved for Alzheimer's disease (AD) and these act to control symptoms rather than …

The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

The goal of this guideline is to improve the care of patients with dementia who are exhibiting
agitation or psychosis. More specifically, this guideline focuses on the judicious use of …