Ran GTPase and its importance in cellular signaling and malignant phenotype

M El-Tanani, H Nsairat, V Mishra, Y Mishra… - International journal of …, 2023 - mdpi.com
Ran is a member of the Ras superfamily of proteins, which primarily regulates
nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and …

Competing endogenous RNA networks in glioma

L Cen, R Liu, W Liu, Q Li, H Cui - Frontiers in Genetics, 2021 - frontiersin.org
Gliomas are the most common and malignant primary brain tumors. Various hallmarks of
glioma, including sustained proliferation, migration, invasion, heterogeneity, radio-and …

The cell cycle‐related genes RHAMM, AURKA, TPX2, PLK1, and PLK4 are associated with the poor prognosis of breast cancer patients

I Kahl, J Mense, C Finke, AL Boller… - Journal of Cellular …, 2022 - Wiley Online Library
Breast cancer is the third most common type of cancer diagnosed. Cell cycle is a complex
but highly organized and controlled process, in which normal cells sense mitogenic growth …

Identification of biomarkers correlated with the TNM staging and overall survival of patients with bladder cancer

S Li, X Liu, T Liu, X Meng, X Yin, C Fang… - Frontiers in …, 2017 - frontiersin.org
Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with
bladder cancer (BC). Methods: Weighted gene co-expression network analysis was applied …

TPX2 silencing exerts anti-tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway

DH Huang, J Jian, S Li, Y Zhang… - … Journal of Molecular …, 2019 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is one of the primary causes of cancer-associated deaths
worldwide. Current treatment methods include surgical resection, chemotherapy and …

TPX2 level correlates with hepatocellular carcinoma cell proliferation, apoptosis, and EMT

B Liang, C Jia, Y Huang, H He, J Li, H Liao… - Digestive diseases and …, 2015 - Springer
Abstract Background Targeting protein for Xklp2 (TPX2) is a microtubule-associated protein
involved in targeting the motor protein Xklp2 to microtubules. TPX2 overexpression plays a …

miR-485-3p suppresses colorectal cancer via targeting TPX2.

K Taherdangkoo, KN SR… - Bratislava Medical …, 2020 - search.ebscohost.com
Abstract BACKGROUND: Colorectal cancer (CRC), is the third most common cancer type.
MicroRNAs and their roles in cancer progression have gained considerable attention in the …

CircPOSTN/miR-361-5p/TPX2 axis regulates cell growth, apoptosis and aerobic glycolysis in glioma cells

N Long, L Chu, J Jia, S Peng, Y Gao, H Yang… - Cancer Cell …, 2020 - Springer
Background Glioma is the most primary central nervous system tumor in adults. The 5 year
survival rate for glioma patients remains poor, although treatment strategies had improved in …

Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast …

M Chen, H Zhang, G Zhang, A Zhong, Q Ma… - Biochemical and …, 2018 - Elsevier
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated
protein required for mitosis and spindle assembly. Previous studies showed that TPX2 is …

TPX2 is a prognostic marker and contributes to growth and metastasis of human hepatocellular carcinoma

Y Huang, W Guo, H Kan - International journal of molecular sciences, 2014 - mdpi.com
Targeting protein for Xenopus kinesin-like protein 2 (TPX2), a microtubule-associated
protein, impacts spindle assembly in human cells. Several studies have demonstrated that …