[HTML][HTML] The horse as a model of naturally occurring osteoarthritis

CW McIlwraith, DD Frisbie, CE Kawcak - Bone & joint research, 2012 - boneandjoint.org.uk
Osteoarthritis (OA) is an important cause of pain, disability and economic loss in humans,
and is similarly important in the horse. Recent knowledge on post-traumatic OA has …

[图书][B] The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

J Bondeson, AB Blom, S Wainwright, C Hughes… - 2012 - academia.edu
Osteoarthritis (OA), one of the most common diseases among humans, is characterised
pathologically by focal areas of damage on articular cartilage centred on load-bearing …

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

Y Hu, Z Gui, Y Zhou, L Xia, K Lin, Y Xu - Free Radical Biology and …, 2019 - Elsevier
Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the
degeneration and destruction of the articular cartilage. Cartilage matrix degradation …

[HTML][HTML] Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

VB Kraus, B Burnett, J Coindreau, S Cottrell… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …

[HTML][HTML] The efficacy and safety of disease-modifying osteoarthritis drugs for knee and hip osteoarthritis—a systematic review and network meta-analysis

W Yang, C Sun, SQ He, JY Chen, Y Wang… - Journal of General …, 2021 - Springer
Background Osteoarthritis (OA) is common and burdensome for patients and health care
systems. Our study purpose was to evaluate the long-term efficacy and safety of DMOADs in …

Evaluation of the articular cartilage of the knee joint: value of adding a T2 mapping sequence to a routine MR imaging protocol

R Kijowski, DG Blankenbaker, A Munoz del Rio… - Radiology, 2013 - pubs.rsna.org
Purpose To determine whether the addition of a T2 mapping sequence to a routine magnetic
resonance (MR) imaging protocol could improve diagnostic performance in the detection of …

Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission

X Yao, X Jing, Y Ye, J Guo, K Sun, F Guo - Pharmacological research, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative disease characterized by progressive loss of cartilage,
osteophyte formation and subchondral bone sclerosis. Although some animal experiments …

Lipid metabolism and osteoarthritis: lessons from atherosclerosis

V Gkretsi, T Simopoulou, A Tsezou - Progress in lipid research, 2011 - Elsevier
Osteoarthritis (OA) is an age-related degenerative disease comprising the main reason of
handicap in the Western world. Interestingly, to date, there are neither available biomarkers …

[PDF][PDF] Toward a clinical definition of early osteoarthritis: onset of patient‐reported knee pain begins on stairs. Data from the osteoarthritis initiative

EMA Hensor, B Dube, SR Kingsbury… - Arthritis care & …, 2015 - Wiley Online Library
Objective Early detection of osteoarthritis (OA) would increase the chances of effective
intervention. We aimed to investigate which patient‐reported activity is first associated with …

[HTML][HTML] Osteoarthritis year 2012 in review: biomarkers

A Mobasheri - Osteoarthritis and Cartilage, 2012 - Elsevier
PURPOSE: Biomarkers provide useful diagnostic information by detecting cartilage
degradation in osteoarthritis (OA), reflecting disease-relevant biological activity and …