The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

Four decades have passed since the first discovery of collagen IV by Kefalides in 1966.
Since then collagen IV has been investigated extensively by a large number of research …

The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …

Laminin (Ln) and collagen are multifunctional glycoproteins that play an important role in
cellular morphogenesis, cell signalling, tissue repair and cell migration. These proteins are …

Peptide-based drug delivery systems have many advantages when compared to synthetic
systems in that they have better biocompatibility, biochemical and biophysical properties …

The lens capsule is a modified basement membrane that completely surrounds the ocular
lens. It is known that this extracellular matrix is important for both the structure and …

MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were
coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r 1, of nearly …

Chronic vascular disease in diabetes is associated with disruption of extracellular matrix
(ECM) interactions with adherent endothelial cells, compromising cell survival and impairing …

Piezo1 is a recently discovered Ca2+ permeable ion channel that has emerged as an
integral sensor of hemodynamic forces within the cardiovascular system, contributing to …

Integrins are transmembrane proteins that mediate cellular adhesion and migration to
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …