The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

The primary site of Ras signal transduction is the plasma membrane (PM). On the PM, the
ubiquitously expressed Ras isoforms, H-, N-, and K-Ras, spatially segregate to …

Self-assembly of plasma membrane-associated Ras GTPases has major implications to the
regulation of cell signaling. However, the structural basis of homo-oligomerization and the …

Abstract Caveolin-1 (cav-1) is an important player in cell signaling and endocytosis that has
been shown to colocalize with cholesterol-rich membrane domains. Experimental studies …

Cellular membranes are laterally organized into domains of distinct structures and
compositions by the differential interaction affinities between various membrane lipids and …

Inter-leaflet coupling is critical to control the dynamics of membrane domain registration/anti-
registration, which is important in maintaining proper biological functions. Factors such as …

Biological membranes contain a broad variety of lipid species whose individual
physicochemical properties and collective interactions ultimately determine membrane …

Chitooligosaccharides (COS) have a variety of biological activities due to their positively
charged amino groups. Studies have shown that COS have antidiabetic effects, but their …

RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active
and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants …

Docosahexaenoic acid (DHA) is a ω-3 polyunsaturated fatty acid, which can be uptaken by
cells and is essential for proper neuronal and retinal function. However, the detailed …