Connexins: a myriad of functions extending beyond assembly of gap junction channels
HA Dbouk, RM Mroue, ME El-Sabban… - Cell Communication and …, 2009 - Springer
Connexins constitute a large family of trans-membrane proteins that allow intercellular
communication and the transfer of ions and small signaling molecules between cells …
communication and the transfer of ions and small signaling molecules between cells …
[HTML][HTML] Defective gap junctional intercellular communication in the carcinogenic process
Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status
A cell line representative of human high-grade serous ovarian cancer (HGSOC) should not
only resemble its tumour of origin at the molecular level, but also demonstrate functional …
only resemble its tumour of origin at the molecular level, but also demonstrate functional …
Gap junctions and cancer: new functions for an old story
Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …
the evidence accumulated over the last 40-year period, the molecular involvement of gap …
Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer
L Kanczuga-Koda, S Sulkowski, A Lenczewski… - Journal of clinical …, 2006 - jcp.bmj.com
Background: Gap junctions are intercellular channels composed of connexins, which
mediate the direct passage of small molecules between neighbouring cells. They are …
mediate the direct passage of small molecules between neighbouring cells. They are …
Gap junctions and connexins as therapeutic targets in cancer
M Kandouz, G Batist - Expert opinion on therapeutic targets, 2010 - Taylor & Francis
Importance of the field: Connexins (Cxs) and gap junctional intercellular communications
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …
Metastasis suppressor genes: at the interface between the environment and tumor cell growth
The molecular mechanisms and genetic programs required for cancer metastasis are
sometimes overlapping, but components are clearly distinct from those promoting growth of …
sometimes overlapping, but components are clearly distinct from those promoting growth of …
Mechanisms governing metastatic dormancy in breast cancer
J Dittmer - Seminars in cancer biology, 2017 - Elsevier
Breast cancer is a systemic disease characterized by early dissemination of tumor cells to
distant organs. In this foreign environment, tumor cells may stay in a dormant state as single …
distant organs. In this foreign environment, tumor cells may stay in a dormant state as single …
[HTML][HTML] Metastasis suppressors: functional pathways
I Khan, PS Steeg - Laboratory Investigation, 2018 - Elsevier
Metastasis is a complex process and a major contributor of death in cancer patients.
Metastasis suppressor genes are identified by their ability to inhibit metastasis at a …
Metastasis suppressor genes are identified by their ability to inhibit metastasis at a …
Downregulation of gap junctions in cancer cells
E Leithe, S Sirnes, Y Omori… - Critical Reviews™ in …, 2006 - dl.begellhouse.com
Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …