A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

Long noncoding RNAs (lncRNAs) are emerging as key parts of multiple cellular pathways,
but their modes of action and how these are dictated by sequence remain unclear. lncRNAs …

Elevated expression of RNA binding protein HNRNPC has been reported in cancer cells,
while the essentialness and functions of HNRNPC in tumors were not clear. We showed that …

The activities of RNA polymerase and the spliceosome are responsible for the heterogeneity
in the abundance and isoform composition of mRNA in human cells. However, the dynamics …

Dysregulated RNA metabolism is emerging as a crucially important mechanism
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …

Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region
(3ʹUTR) length but can also recognize intronic polyadenylation (IpA) signals to generate …

Long mammalian introns make it challenging for the RNA processing machinery to identify
exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection …