Sickle cell disease (SCD) is an inheritable hemoglobinopathy characterized by
polymerization of hemoglobin S in red blood cells resulting in chronic hemolytic anemia …

This study investigated the possible mechanisms underlying the gastroprotective effect of
simvastatin against indomethacin-induced gastric ulcer in rats. Rats were randomly …

Abstract Background and Aim: Recently, statins have appeared to have additional benefits
beyond their lipid lowering effects, which has led to the interest in the use of this class of …

Vascular dementia (VaD) is a degenerative cerebrovascular disorder that leads to
progressive decline in cognitive abilities and memory. Several reports demonstrated that …

Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for
neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3 …

Air particulate pollution negatively affects the health of the population exposed, being the
lung the main target organ. Simvastatin (SV) is widely used for the prevention and risk …

Gastric ulcer is one of the most serious diseases. Nebivolol (Neb), a β1-blocker, exhibits
vasodilator and anti-oxidative properties, simvastatin (Sim) antihyperlipidemic drug, exhibits …

Background It has been reported that simvastatin, a statin commonly prescribed for its anti-
inflammatory and antioxidant effects, has gastroprotective effects in indomethacin and …

Simvastatin is an antilipemic drug that promotes inhibition of HMG-CoA reductase.
Simvastatin can also inhibit the formation of other products, such as isoprenoids, conferring …

Due to their wide use, pharmaceuticals can be discarded, metabolized and excreted into the
environment, potentially affecting aquatic organisms. Lipid-regulating drugs are among the …