Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways

BA Kerwin - Journal of pharmaceutical sciences, 2008 - Elsevier
ABSTRACT Polysorbates 20 and 80 (Tween® 20 and Tween® 80) are used in the
formulation of biotherapeutic products for both preventing surface adsorption and as …

Trends on analytical characterization of polysorbates and their degradation products in biopharmaceutical formulations

A Martos, W Koch, W Jiskoot, K Wuchner… - Journal of …, 2017 - Elsevier
Among many other applications, polysorbates (PSs) are used as the most common
surfactants in biopharmaceutical products in particular to protect proteins against interfacial …

Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH

HA Messal, J Almagro, M Zaw Thin, A Tedeschi… - Nature protocols, 2021 - nature.com
Advances in light-sheet and confocal microscopy now allow imaging of cleared large
biological tissue samples and enable the 3D appreciation of cell and protein localization in …

[HTML][HTML] Molecular mechanism of membrane permeabilization by the peptide antibiotic surfactin

C Carrillo, JA Teruel, FJ Aranda, A Ortiz - Biochimica et Biophysica Acta …, 2003 - Elsevier
Surfactin, an acidic lipopeptide produced by various strains of Bacillus subtilis, behaves as a
very powerful biosurfactant and possesses several other interesting biological activities. This …

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

C Dietrich, ZN Volovyk, M Levi… - Proceedings of the …, 2001 - National Acad Sciences
As shown earlier, raft-like domains resembling those thought to be present in natural cell
membranes can be formed in supported planar lipid monolayers. These liquid-ordered …

Anionic micelles and vesicles induce tau fibrillization in vitro

CN Chirita, M Necula, J Kuret - Journal of Biological Chemistry, 2003 - ASBMB
Alzheimer's disease is defined in part by the intraneuronal accumulation of filaments
comprised of the microtubule-associated protein tau. In vitro, fibrillization of recombinant tau …

[图书][B] Introduction to biological membranes

MK Jain, RC Wagner - 1988 - core.ac.uk
The amount of information generated by intensive studies of biological membranes over the
past years is such that a comprehensive treatise is now a major undertaking. This new …

[HTML][HTML] Oxidation of polysorbates–An underestimated degradation pathway?

J Weber, J Buske, K Mäder, P Garidel… - International Journal of …, 2023 - Elsevier
To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active
compounds (surfactants) are added to protect biologics from denaturation and particle …

Protein sizing on a microchip

L Bousse, S Mouradian, A Minalla, H Yee… - Analytical …, 2001 - ACS Publications
We have developed a microfabricated analytical device on a glass chip that performs a
protein sizing assay, by integrating the required separation, staining, virtual destaining, and …

Nanoparticles and surfaces presenting antifungal, antibacterial and antiviral properties

D Botequim, J Maia, MMF Lino, LMF Lopes… - Langmuir, 2012 - ACS Publications
Here, we present new antimicrobial nanoparticles based on silica nanoparticles (SNPs)
coated with a quaternary ammonium cationic surfactant, didodecyldimethylammonium …