TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Phosphoinositide regulation of TRP channels: A functional overview in the structural era
T Rohacs - Annual Review of Physiology, 2024 - annualreviews.org
Transient receptor potential (TRP) ion channels have diverse activation mechanisms
including physical stimuli, such as high or low temperatures, and a variety of intracellular …
including physical stimuli, such as high or low temperatures, and a variety of intracellular …
Structural mechanisms of TRPM7 activation and inhibition
KD Nadezhdin, L Correia, C Narangoda… - Nature …, 2023 - nature.com
The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …
balance of divalent cations that plays an essential role in embryonic development, immune …
TRPM channels in health and disease
Different cell channels and transporters tightly regulate cytoplasmic levels and the
intraorganelle distribution of cations. Perturbations in these processes lead to human …
intraorganelle distribution of cations. Perturbations in these processes lead to human …
The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis
ME Falzone, R MacKinnon - Proceedings of the National …, 2023 - National Acad Sciences
PLCβ (Phospholipase Cβ) enzymes cleave phosphatidylinositol 4, 5-bisphosphate (PIP2)
producing IP3 and DAG (diacylglycerol). PIP2 modulates the function of many ion channels …
producing IP3 and DAG (diacylglycerol). PIP2 modulates the function of many ion channels …
Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface
ME Falzone, R MacKinnon - Proceedings of the National …, 2023 - National Acad Sciences
Phospholipase C-βs (PLCβs) catalyze the hydrolysis of phosphatidylinositol 4, 5–
bisphosphate (PIP 2) into inositoltriphosphate (IP3) and diacylglycerol (DAG). PIP 2 …
bisphosphate (PIP 2) into inositoltriphosphate (IP3) and diacylglycerol (DAG). PIP 2 …
Implications of TRPM3 and TRPM8 for sensory neuron sensitisation
M Behrendt - Biological Chemistry, 2024 - degruyter.com
Sensory neurons serve to receive and transmit a wide range of information about the
conditions of the world around us as well as the external and internal state of our body …
conditions of the world around us as well as the external and internal state of our body …
Neurodevelopmental disorders caused by variants in TRPM3
Developmental and epileptic encephalopathies (DEE) are a broad and varied group of
disorders that affect the brain and are characterized by epilepsy and comorbid intellectual …
disorders that affect the brain and are characterized by epilepsy and comorbid intellectual …
A cataract-causing mutation in the TRPM3 cation channel disrupts calcium dynamics in the lens
Y Zhou, TM Bennett, PA Ruzycki, Z Guo, YQ Cao… - Cells, 2024 - mdpi.com
TRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation
channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion …
channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion …
Ion channels regulate energy homeostasis and the progression of metabolic disorders: Novel mechanisms and pharmacology of their modulators
W Wu, J Zheng, R Wang, Y Wang - Biochemical Pharmacology, 2023 - Elsevier
The progression of metabolic diseases, featured by dysregulated metabolic signaling
pathways, is orchestrated by numerous signaling networks. Among the regulators, ion …
pathways, is orchestrated by numerous signaling networks. Among the regulators, ion …