Emerging roles for 3′ UTRs in neurons
The 3′ untranslated regions (3′ UTRs) of mRNAs serve as hubs for post-transcriptional
control as the targets of microRNAs (miRNAs) and RNA-binding proteins (RBPs) …
control as the targets of microRNAs (miRNAs) and RNA-binding proteins (RBPs) …
The emerging roles of CFIm25 (NUDT21/CPSF5) in human biology and disease
CP Masamha - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
The mammalian cleavage factor I subunit CFIm25 (NUDT21) binds to the UGUA sequences
of precursor RNAs. Traditionally, CFIm25 is known to facilitate 3′ end formation of pre …
of precursor RNAs. Traditionally, CFIm25 is known to facilitate 3′ end formation of pre …
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6
M Schmidt, F Kluge, F Sandmeir, U Kühn… - Genes & …, 2022 - genesdev.cshlp.org
The 3′ ends of almost all eukaryotic mRNAs are generated in an essential two-step
processing reaction: endonucleolytic cleavage of an extended precursor followed by the …
processing reaction: endonucleolytic cleavage of an extended precursor followed by the …
Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons
ME van der Heijden, EP Lackey, R Perez, FS Ișleyen… - Elife, 2021 - elifesciences.org
Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive
difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially …
difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially …
Alternative polyadenylation alters protein dosage by switching between intronic and 3′ UTR sites
Alternative polyadenylation (APA) creates distinct transcripts from the same gene by
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
Alternative polyadenylation: An enigma of transcript length variation in health and disease
NK Mohanan, F Shaji, GR Koshre… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Alternative polyadenylation (APA) is a molecular mechanism during a pre‐mRNA
processing that involves usage of more than one polyadenylation site (PA‐site) generating …
processing that involves usage of more than one polyadenylation site (PA‐site) generating …
Differential alternative polyadenylation of homoeologous genes of allohexaploid wheat ABD subgenomes during drought stress response
Because allohexaploid wheat genome contains ABD subgenomes, how the expression of
homoeologous genes is coordinated remains largely unknown, particularly at the co …
homoeologous genes is coordinated remains largely unknown, particularly at the co …
PolyA-miner: Accurate assessment of differential alternative poly-adenylation from 3′ Seq data using vector projections and non-negative matrix factorization
Almost 70% of human genes undergo alternative polyadenylation (APA) and generate
mRNA transcripts with varying lengths, typically of the 3′ untranslated regions (UTR). APA …
mRNA transcripts with varying lengths, typically of the 3′ untranslated regions (UTR). APA …
NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1
Purpose Gliomas and their surrounding microenvironment constantly interact to promote
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …
RNAseq Analysis of FABP4 Knockout Mouse Hippocampal Transcriptome Suggests a Role for WNT/β-Catenin in Preventing Obesity-Induced Cognitive Impairment
SW So, JP Nixon, DA Bernlohr, TA Butterick - International journal of …, 2023 - mdpi.com
Microglial fatty-acid binding protein 4 (FABP4) is a regulator of neuroinflammation. We
hypothesized that the link between lipid metabolism and inflammation indicates a role for …
hypothesized that the link between lipid metabolism and inflammation indicates a role for …