A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

Chronic active Epstein–Barr virus (CAEBV) disease is a rare disorder in which persons are
unable to control infection with the virus. The disease is progressive with markedly elevated …

The granule exocytosis pathway of cytotoxic lymphocytes is crucial for immune surveillance
and homeostasis. The trafficking of granule components, including the membrane-disruptive …

Chronic active EBV disease (CAEBV) is a lymphoproliferative disorder characterized by
markedly elevated levels of antibody to EBV or EBV DNA in the blood and EBV RNA or …

Perforin is a glycoprotein responsible for pore formation in cell membranes of target cells.
Perforin is able to polymerize and form a channel in target cell membrane. many research …

Epstein–Barr virus (EBV) is a ubiquitous virus that infects nearly all people worldwide
without serious sequela. However, for patients who have genetic diseases which predispose …

Since the initial report of unusual manifestations possibly associated with chronic active
Epstein‐Barr virus (EBV) infection (CAEBV), nearly three decades have passed. During this …

Abstract Background Recently novel Epstein–Barr virus (EBV) lymphoproliferative diseases
(LPDs) have been identified in non-immunocompromised hosts, both in Asia and Western …

The secretory granule‐mediated cell death pathway is the key mechanism for elimination of
virus‐infected and transformed target cells by cytotoxic lymphocytes. The formation of the …

Epstein-Barr virus (EBV) infects nearly all humans and usually is asymptomatic, or in the
case of adolescents and young adults, it can result in infectious mononucleosis. EBV …