Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms

H Lu, W Du, L Ren, MH Hamblin… - Journal of the …, 2021 - Am Heart Assoc
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Y Kojima, JP Volkmer, K McKenna, M Civelek, AJ Lusis… - Nature, 2016 - nature.com
Atherosclerosis is the disease process that underlies heart attack and stroke. Advanced
lesions at risk of rupture are characterized by the pathological accumulation of diseased …

[HTML][HTML] The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm

EL Chaikof, RL Dalman, MK Eskandari… - Journal of vascular …, 2018 - Elsevier
Background Decision-making related to the care of patients with an abdominal aortic
aneurysm (AAA) is complex. Aneurysms present with varying risks of rupture, and patient …

The latest advances in the reproductive toxicity of microcystin-LR

S Zhang, X Du, H Liu, MD Losiewic, X Chen, Y Ma… - Environmental …, 2021 - Elsevier
Abstract Microcystin-LR (MC-LR) is an emerging environmental pollutant produced by
cyanobacteria that poses a threat to wild life and human health. In recent years, the …

The role of efferocytosis in atherosclerosis

Y Kojima, IL Weissman, NJ Leeper - Circulation, 2017 - Am Heart Assoc
The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque.
Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal …

H19 induces abdominal aortic aneurysm development and progression

DY Li, A Busch, H Jin, E Chernogubova, J Pelisek… - Circulation, 2018 - Am Heart Assoc
Background: Long noncoding RNAs have emerged as critical molecular regulators in
various biological processes and diseases. Here we sought to identify and functionally …

[HTML][HTML] The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice guidelines

EL Chaikof, DC Brewster, RL Dalman… - Journal of vascular …, 2009 - jvascsurg.org
The Clinical Practice Council of the Society for Vascular Surgery charged a writing
committee with the task of updating practice guidelines, initally published in 2003, for …

Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Skeletal muscle transcriptome in healthy aging

RA Tumasian III, A Harish, G Kundu, JH Yang… - Nature …, 2021 - nature.com
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …