Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

Epidemiologic studies have previously suggested that premenopausal females have
reduced incidence of cardiovascular disease (CVD) when compared to age-matched males …

Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17
million people die worldwide from CVD per year. There is considerable evidence suggesting …

Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …

Recent clinical and experimental studies are redefining the cellular and molecular bases of
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …

Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Pregnancy outcomes in patients with pulmonary hypertension remain poor despite
advanced therapies. Although consensus guidelines recommend against pregnancy in …

Rationale: Idiopathic pulmonary arterial hypertension (PAH) is a terminal pulmonary
vascular disease characterized by increased pressure, right ventricular failure, and death …

Background Male sex is an independent predictor of worse survival in pulmonary arterial
hypertension (PAH). This finding might be explained by more severe pulmonary vascular …