The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Stimuli-responsive polymers are promising to achieve targeted delivery, improved stability
during circulation, and controlled release of therapeutic and diagnostic agents. Among them …

New preparation methods of vectors are the key to developing the next generation of
biomacromolecule delivery systems. In this study, a controllable disulfide exchange …

Biologics, including proteins and antisense oligonucleotides (ASOs), face significant
challenges when it comes to achieving intracellular delivery within specific organs or cells …

Highlights•CPD is formed by thiolate-initiated ring-opening polymerization, which requires
three components: an initiator, a monomer and a terminator.•CPD can mediate thiol …

Therapeutic proteins provided new opportunities for patients and high sales volumes.
However, they are formulated for extracellular targets. The lipophilic barrier of the plasma …

The utilization of cytosolic protein delivery is a promising approach for treating various
diseases by replacing dysfunctional proteins. Despite the development of various …

The structure and function of the tumor microenvironment (TME) are closely related to the
occurrence and metastasis of tumors. It not only provides an infiltration site for tumor cells …