Astrocytes perform a wide variety of essential functions defining normal operation of the
nervous system and are active contributors to the pathogenesis of neurodegenerative …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …

Under physiological conditions in vivo astrocytes internalize and degrade neuronal
mitochondria in a process called transmitophagy. Mitophagy is widely reported to be …

Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there
is a growing body of evidence showing that, in the hippocampus, this process contributes to …

Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria due to their higher bioenergetic demand. Mitochondrial dysfunction is closely …

Myocardial ischemia–reperfusion (I/R) injury is one of the leading causes of death and
disability worldwide. Mitochondrial fission has been shown to be involved in cardiomyocyte …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

Abstract The glucagon-like peptide-1 (GLP-1) was shown to have neuroprotective effects in
Alzheimer's disease (AD). However, the underlying mechanism remains elusive. Astrocytic …

Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear
whether and how exosomes modulate Aβ neurotoxicity in Alzheimer's disease (AD). We …