Human NK cells, their receptors and function
NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of
defense against viral infections and contribute to control tumor growth and metastasis. Their …
defense against viral infections and contribute to control tumor growth and metastasis. Their …
Bi-specific and tri-specific NK cell engagers: the new avenue of targeted NK cell immunotherapy
SK Phung, JS Miller, M Felices - Molecular Diagnosis & Therapy, 2021 - Springer
Natural killer (NK) cell-mediated cancer immunotherapy has grown significantly over the
past two decades. More recently, multi-specific engagers have been developed as cancer …
past two decades. More recently, multi-specific engagers have been developed as cancer …
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression
Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …
HLA class I molecules as immune checkpoints for NK cell alloreactivity and anti-viral immunity in kidney transplantation
B Duygu, TI Olieslagers, M Groeneweg… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells are innate lymphocytes that can kill diseased-or virally-infected cells,
mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines …
mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines …
Recombinant human interleukin-2 corrects NK cell phenotype and functional activity in patients with post-COVID syndrome
AA Savchenko, IV Kudryavtsev, DV Isakov… - Pharmaceuticals, 2023 - mdpi.com
Post-COVID syndrome develops in 10–20% of people who have recovered from COVID-19
and it is characterized by impaired function of the nervous, cardiovascular, and immune …
and it is characterized by impaired function of the nervous, cardiovascular, and immune …
NK cell subsets and dysfunction during viral infection: a new avenue for therapeutics?
JC Bjorgen, JK Dick, R Cromarty, GT Hart… - Frontiers in …, 2023 - frontiersin.org
In the setting of viral challenge, natural killer (NK) cells play an important role as an early
immune responder against infection. During this response, significant changes in the NK cell …
immune responder against infection. During this response, significant changes in the NK cell …
Clean up by aisle 2: roles for IL-2 receptors in host defense and tolerance
EWY Hsieh, JD Hernandez - Current Opinion in Immunology, 2021 - Elsevier
Although IL-2 was first recognized as growth factor for T cells, it is now also appreciated to
be a key regulator of T cells through its effects on regulatory T cells (Treg). The IL-2 receptor …
be a key regulator of T cells through its effects on regulatory T cells (Treg). The IL-2 receptor …
Human cytomegalovirus infection and cardiovascular disease: current perspectives
Infections with human cytomegalovirus (HCMV) are often asymptomatic in healthy adults but
can be severe in people with a compromised immune system. While several studies have …
can be severe in people with a compromised immune system. While several studies have …
A hot topic: Cancer immunotherapy and natural killer cells
Despite significant progress in recent years, the therapeutic approach of the multiple
different forms of human cancer often remains a challenge. Besides the well-established …
different forms of human cancer often remains a challenge. Besides the well-established …
[HTML][HTML] A Critical Role of Culture Medium Selection in Maximizing the Purity and Expansion of Natural Killer Cells
N Kusch, J Storm, A Macioszek, E Kisselmann… - Cells, 2024 - mdpi.com
Natural killer (NK) cells hold promise in cancer treatment due to their ability to
spontaneously lyse cancer cells. For clinical use, high quantities of pure, functional NK cells …
spontaneously lyse cancer cells. For clinical use, high quantities of pure, functional NK cells …