Moving beyond the glial scar for spinal cord repair
EJ Bradbury, ER Burnside - Nature communications, 2019 - nature.com
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …
triggers a complex cascade of inflammatory and pathological processes, culminating in …
The biology of regeneration failure and success after spinal cord injury
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
Blood–spinal cord barrier in spinal cord injury: a review
LY Jin, J Li, KF Wang, WW Xia, ZQ Zhu… - Journal of …, 2021 - liebertpub.com
The blood–spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …
Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …
individuals and society. The goal of research in this field is to find a means of restoring lost …
Dissecting the dual role of the glial scar and scar-forming astrocytes in spinal cord injury
T Yang, YJ Dai, G Chen, SS Cui - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …
Inflammogenesis of secondary spinal cord injury
MA Anwar, TS Al Shehabi, AH Eid - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Spinal cord injury (SCI) and spinal infarction lead to neurological complications and
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …
Advances in biomaterial‐based spinal cord injury repair
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …
challenge in neurological clinical practice. Understanding the pathophysiological changes …
Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury
DJ Donnelly, PG Popovich - Experimental neurology, 2008 - Elsevier
Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and
activation of systemic immunity with the capacity to exacerbate neuropathology and …
activation of systemic immunity with the capacity to exacerbate neuropathology and …
Human astrocytes express a novel NLRP2 inflammasome
J Minkiewicz, JP de Rivero Vaccari, RW Keane - Glia, 2013 - Wiley Online Library
Central nervous system (CNS) trauma involves extensive cellular damage that is due, in
part, to an innate inflammatory response induced by extracellular ATP. The innate immune …
part, to an innate inflammatory response induced by extracellular ATP. The innate immune …
Concise review: bridging the gap: novel neuroregenerative and neuroprotective strategies in spinal cord injury
CS Ahuja, M Fehlings - Stem cells translational medicine, 2016 - academic.oup.com
Spinal cord injuries (SCIs) result in devastating lifelong disability for patients and their
families. The initial mechanical trauma is followed by a damaging secondary injury cascade …
families. The initial mechanical trauma is followed by a damaging secondary injury cascade …