Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

The blood–spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …

Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …

Spinal cord injury (SCI) and spinal infarction lead to neurological complications and
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …

Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and
activation of systemic immunity with the capacity to exacerbate neuropathology and …

Central nervous system (CNS) trauma involves extensive cellular damage that is due, in
part, to an innate inflammatory response induced by extracellular ATP. The innate immune …

Spinal cord injuries (SCIs) result in devastating lifelong disability for patients and their
families. The initial mechanical trauma is followed by a damaging secondary injury cascade …