Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …

Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living
organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of …

Radicals in biology, once thought to all be bad actors, are now known to play a central role
in many enzymatic reactions. Of the known radical-based enzymes, ribonucleotide …

Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of
chemotherapy. How mannose exerts its anticancer activity, however, remains poorly …

Viruses use a plethora of mechanisms to evade immune responses. A recent example is
neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus …

Ribonucleotide reductase (RNR) is an essential enzyme that converts ribonucleotides to
deoxyribonucleotides and is a promising antibiotic target, but few RNRs have been …

Abstract Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health
threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two …

Class Ia ribonucleotide reductases (RNRs) are allosterically regulated by ATP and dATP to
maintain the appropriate deoxyribonucleotide levels inside the cell for DNA biosynthesis …

Control of cellular identity requires coordination of developmental programs with
environmental factors such as nutrient availability, suggesting that perturbing metabolism …