VCP/p97-mediated unfolding as a principle in protein homeostasis and signaling
J van den Boom, H Meyer - Molecular cell, 2018 - cell.com
The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes
reaching from degradation of damaged proteins and organelles to key signaling events and …
reaching from degradation of damaged proteins and organelles to key signaling events and …
Environmental factors modulating protein conformations and their role in protein aggregation diseases
The adverse physiological conditions have been long known to impact protein synthesis,
folding and functionality. Major physiological factors such as the effect of pH, temperature …
folding and functionality. Major physiological factors such as the effect of pH, temperature …
ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules
A Turakhiya, SR Meyer, G Marincola, S Böhm… - Molecular cell, 2018 - cell.com
Stress granules (SGs) are cytoplasmic assemblies of mRNPs stalled in translation initiation.
They are induced by various stress conditions, including exposure to the environmental …
They are induced by various stress conditions, including exposure to the environmental …
Potential use of the Pteris vittata arsenic hyperaccumulation-regulation network for phytoremediation
H Yan, Y Gao, L Wu, L Wang, T Zhang, C Dai… - Journal of hazardous …, 2019 - Elsevier
Arsenic accumulation in soil is a global problem typically addressed using phytoremediation
methods. Pteris vittata, a model arsenic hyperaccumulator, has great potential as a …
methods. Pteris vittata, a model arsenic hyperaccumulator, has great potential as a …
Chemistry, pharmacology, and toxicology of monoisoamyl dimercaptosuccinic acid: a chelating agent for chronic metal poisoning
Arsenic, a metalloid, is known to cause deleterious effects in various body organs,
particularly the liver, urinary bladder, and brain, and these effects are primarily mediated …
particularly the liver, urinary bladder, and brain, and these effects are primarily mediated …
Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system
N Tolay, A Buchberger - Life Science Alliance, 2021 - life-science-alliance.org
Stress granules (SGs) are cytoplasmic condensates containing untranslated mRNP
complexes. They are induced by various proteotoxic conditions such as heat, oxidative, and …
complexes. They are induced by various proteotoxic conditions such as heat, oxidative, and …
Arsenic exposure and compromised protein quality control
Exposure to arsenic in contaminated drinking water is a worldwide public health problem
that affects more than 200 million people. Protein quality control constitutes an evolutionarily …
that affects more than 200 million people. Protein quality control constitutes an evolutionarily …
Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony
Arsenic and antimony are metalloids with profound effects on biological systems and human
health. Both elements are toxic to cells and organisms, and exposure is associated with …
health. Both elements are toxic to cells and organisms, and exposure is associated with …
Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development
X Yang, AA Weber, E Mennillo, P Secrest… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Newborns can be exposed to inorganic arsenic (iAs) through contaminated
drinking water, formula, and other infant foods. Epidemiological studies have demonstrated …
drinking water, formula, and other infant foods. Epidemiological studies have demonstrated …
[HTML][HTML] DNA methylation analysis reveals the effect of arsenic on gestational diabetes mellitus
Y Gao, H Wang, G Fu, Y Feng, W Wu, H Yang, Y Zhang… - Genomics, 2023 - Elsevier
Abstract Background Arsenic (As) exposure is one of the risk factors for gestational diabetes
mellitus (GDM). This study aimed to explore the effect of As-exposure on DNA methylation in …
mellitus (GDM). This study aimed to explore the effect of As-exposure on DNA methylation in …