VCP/p97-mediated unfolding as a principle in protein homeostasis and signaling

J van den Boom, H Meyer - Molecular cell, 2018 - cell.com
The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes
reaching from degradation of damaged proteins and organelles to key signaling events and …

Environmental factors modulating protein conformations and their role in protein aggregation diseases

S Devi, M Chaturvedi, S Fatima, S Priya - Toxicology, 2022 - Elsevier
The adverse physiological conditions have been long known to impact protein synthesis,
folding and functionality. Major physiological factors such as the effect of pH, temperature …

ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules

A Turakhiya, SR Meyer, G Marincola, S Böhm… - Molecular cell, 2018 - cell.com
Stress granules (SGs) are cytoplasmic assemblies of mRNPs stalled in translation initiation.
They are induced by various stress conditions, including exposure to the environmental …

Potential use of the Pteris vittata arsenic hyperaccumulation-regulation network for phytoremediation

H Yan, Y Gao, L Wu, L Wang, T Zhang, C Dai… - Journal of hazardous …, 2019 - Elsevier
Arsenic accumulation in soil is a global problem typically addressed using phytoremediation
methods. Pteris vittata, a model arsenic hyperaccumulator, has great potential as a …

Chemistry, pharmacology, and toxicology of monoisoamyl dimercaptosuccinic acid: a chelating agent for chronic metal poisoning

SJS Flora, K Jain, A Panghal… - Chemical research in …, 2022 - ACS Publications
Arsenic, a metalloid, is known to cause deleterious effects in various body organs,
particularly the liver, urinary bladder, and brain, and these effects are primarily mediated …

Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system

N Tolay, A Buchberger - Life Science Alliance, 2021 - life-science-alliance.org
Stress granules (SGs) are cytoplasmic condensates containing untranslated mRNP
complexes. They are induced by various proteotoxic conditions such as heat, oxidative, and …

Arsenic exposure and compromised protein quality control

LM Tam, Y Wang - Chemical research in toxicology, 2020 - ACS Publications
Exposure to arsenic in contaminated drinking water is a worldwide public health problem
that affects more than 200 million people. Protein quality control constitutes an evolutionarily …

Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony

R Wysocki, JI Rodrigues, I Litwin, MJ Tamás - Cellular and Molecular Life …, 2023 - Springer
Arsenic and antimony are metalloids with profound effects on biological systems and human
health. Both elements are toxic to cells and organisms, and exposure is associated with …

Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development

X Yang, AA Weber, E Mennillo, P Secrest… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Newborns can be exposed to inorganic arsenic (iAs) through contaminated
drinking water, formula, and other infant foods. Epidemiological studies have demonstrated …

[HTML][HTML] DNA methylation analysis reveals the effect of arsenic on gestational diabetes mellitus

Y Gao, H Wang, G Fu, Y Feng, W Wu, H Yang, Y Zhang… - Genomics, 2023 - Elsevier
Abstract Background Arsenic (As) exposure is one of the risk factors for gestational diabetes
mellitus (GDM). This study aimed to explore the effect of As-exposure on DNA methylation in …