Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

How metabolism is reprogrammed during neuronal differentiation is unknown. We found that
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …

Inactivation of ARID1A and other components of the nuclear SWI/SNF protein complex
occurs at very high frequencies in a variety of human malignancies, suggesting a …

Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect
vectors separated by hundreds of millions of years of evolutionary history. Entry into …

Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell
resource, with potential for studying disease and use in regenerative medicine. However …

The ectopic expression of transcription factors can reprogram cell fate, yet it is unknown how
the initial binding of factors to the genome relates functionally to the binding seen in the …

In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-
rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each …

Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …