Botulinum neurotoxins: biology, pharmacology, and toxicology
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
Membrane repair: mechanisms and pathophysiology
ST Cooper, PL McNeil - Physiological reviews, 2015 - journals.physiology.org
Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …
plasma membrane injuries, including those caused by osmotic stress, by infection from …
Identifying SNARE proteins using an alignment-free method based on multiscan convolutional neural network and PSSM profiles
Background: SNARE proteins play a vital role in membrane fusion and cellular physiology
and pathological processes. Many potential therapeutics for mental diseases or even cancer …
and pathological processes. Many potential therapeutics for mental diseases or even cancer …
Membrane fusion: grappling with SNARE and SM proteins
TC Südhof, JE Rothman - Science, 2009 - science.org
The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …
SNAP receptors implicated in vesicle targeting and fusion
T Söllner, SW Whiteheart, M Brunner… - Nature, 1993 - nature.com
The N-ethylmaleimide-sensitive fusion protein (NSF) and the soluble NSF attachment
proteins (SNAPs) appear to be essential components of the intracellular membrane fusion …
proteins (SNAPs) appear to be essential components of the intracellular membrane fusion …
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
The evolutionarily conserved SNARE proteins and their complexes are involved in the
fusion of vesicles with their target membranes; however, the overall organization and …
fusion of vesicles with their target membranes; however, the overall organization and …
[HTML][HTML] SNAREpins: minimal machinery for membrane fusion
Recombinant v-and t-SNARE proteins reconstituted into separate lipid bilayer vesicles
assemble into SNAREpins—SNARE complexes linking two membranes. This leads to …
assemble into SNAREpins—SNARE complexes linking two membranes. This leads to …
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
T Söllner, MK Bennett, SW Whiteheart, RH Scheller… - Cell, 1993 - cell.com
The SNARE hypothesis holds that a transport vesicle chooses its target for fusion when a
soluble NSF attachment protein (SNAP) receptor on the vesicle (V-SNARE) pairs with its …
soluble NSF attachment protein (SNAP) receptor on the vesicle (V-SNARE) pairs with its …
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
J Blasi, ER Chapman, E Link, T Binz, S Yamasaki… - Nature, 1993 - nature.com
NEUROTRANSMITTER release is potently blocked by a group of structurally related toxin
proteins produced by Clostridium botulinum 1. Botulinum neurotoxin type B (BoNT/B) and …
proteins produced by Clostridium botulinum 1. Botulinum neurotoxin type B (BoNT/B) and …
SNARE-mediated membrane fusion
YA Chen, RH Scheller - Nature reviews Molecular cell biology, 2001 - nature.com
SNARE proteins have been proposed to mediate all intracellular membrane fusion events.
There are over 30 SNARE family members in mammalian cells and each is found in a …
There are over 30 SNARE family members in mammalian cells and each is found in a …