Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …

Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the
function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar …

Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality.
In recent years, the concept of the neurovascular unit (NVU) has been accepted by an …

Oxidative stress is associated with the progression of Alzheimer's disease (AD). Reactive
oxygen species can modify lipids, DNA, RNA, and proteins in the brain. The products of their …

Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …

Traumatic brain injury (TBI) is one of the leading causes of neurological disability in young
adults. Edaravone, a novel synthetic small-molecule free-radical scavenger, has been …

Similar to peripheral immune/inflammatory cells, neuroglial cells appear to rely on
calcineurin (CN) signaling pathways to regulate cytokine production and cellular activation …