Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive
production or activation of osteoclasts leads to skeletal pathologies that affect a significant …

Fluorescence imaging techniques have been widely used to visualize biological molecules
and phenomena. In particular, several studies on the development of small-molecule …

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

Tissue engineering strategies for treating bone loss to date have largely focused on
targeting stem cells or vascularization. Immune cells, including macrophages and T cells …

Discovery and characterization of the cytokine receptor-cytokine-decoy receptor triad formed
by receptor activator of nuclear factor kappa-B ligand (RANKL)–receptor activator of NF-κB …

Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …

In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …

Bone metabolism is regulated by the cooperative activity between bone-forming osteoblasts
and bone-resorbing osteoclasts. However, the mechanisms mediating the switch between …

Osteoclasts (OCLs) are key players in controlling bone remodeling. Modifications in their
differentiation or bone resorbing activity are associated with a number of pathologies …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation
of the synovial lining (synovitis). The inflammation in the RA joint is associated with and …