Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use
A Skrzypczak-Wiercioch, K Sałat - Molecules, 2022 - mdpi.com
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its
consequences still remain a significant problem in medicine. Acute inflammatory responses …
consequences still remain a significant problem in medicine. Acute inflammatory responses …
Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration
CRA Batista, GF Gomes, E Candelario-Jalil… - International journal of …, 2019 - mdpi.com
A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …
pathological event triggering and perpetuating the neurodegenerative process associated …
Recent advances in lipopolysaccharide recognition systems
L Mazgaeen, P Gurung - International journal of molecular sciences, 2020 - mdpi.com
Lipopolysaccharide (LPS), commonly known as endotoxin, is ubiquitous and the most-
studied pathogen-associated molecular pattern. A component of Gram-negative bacteria …
studied pathogen-associated molecular pattern. A component of Gram-negative bacteria …
[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
Inflammation, cancer and immunity—implication of TRPV1 channel
JK Bujak, D Kosmala, IM Szopa, K Majchrzak… - Frontiers in …, 2019 - frontiersin.org
Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …
tumor microenvironment are known to drive and shape the outcome of the neoplastic …
Antioxidant and neuroprotective effects of caffeine against Alzheimer's and Parkinson's disease: Insight into the role of Nrf-2 and A2AR signaling
This paper reviews the results of studies conducted on the role of caffeine in the
management of different neurological disorders, such as Parkinson's disease (PD) and …
management of different neurological disorders, such as Parkinson's disease (PD) and …
The crosstalk between pattern-recognition receptor signaling and calcium signaling
F Kong, H You, K Zheng, R Tang, C Zheng - International Journal of …, 2021 - Elsevier
The innate immune system is the first line of host defense, and it is capable of resisting both
exogenous pathogenic challenges and endogenous danger signals via different pattern …
exogenous pathogenic challenges and endogenous danger signals via different pattern …
Trpv protein family—From mechanosensing to cancer invasion
T Kärki, S Tojkander - Biomolecules, 2021 - mdpi.com
Biophysical cues from the cellular microenvironment are detected by mechanosensitive
machineries that translate physical signals into biochemical signaling cascades. At the …
machineries that translate physical signals into biochemical signaling cascades. At the …
Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 …
Abstract Maresin-2 (MaR2) is a specialized pro-resolution lipid mediator (SPM) that reduces
neutrophil recruitment in zymosan peritonitis. Here, we investigated the analgesic effect of …
neutrophil recruitment in zymosan peritonitis. Here, we investigated the analgesic effect of …
Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury
Z Liu, P Wang, S Lu, R Guo, W Gao, H Tong, Y Yin… - Cell calcium, 2020 - Elsevier
TRPV1 and TRPA1 are cation channels that play key roles in inflammatory signaling
pathways. They are co-expressed on airway C-fibers, where they exert synergistic effects on …
pathways. They are co-expressed on airway C-fibers, where they exert synergistic effects on …