Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its
consequences still remain a significant problem in medicine. Acute inflammatory responses …

A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Lipopolysaccharide (LPS), commonly known as endotoxin, is ubiquitous and the most-
studied pathogen-associated molecular pattern. A component of Gram-negative bacteria …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

This paper reviews the results of studies conducted on the role of caffeine in the
management of different neurological disorders, such as Parkinson's disease (PD) and …

The innate immune system is the first line of host defense, and it is capable of resisting both
exogenous pathogenic challenges and endogenous danger signals via different pattern …

Biophysical cues from the cellular microenvironment are detected by mechanosensitive
machineries that translate physical signals into biochemical signaling cascades. At the …

Abstract Maresin-2 (MaR2) is a specialized pro-resolution lipid mediator (SPM) that reduces
neutrophil recruitment in zymosan peritonitis. Here, we investigated the analgesic effect of …

TRPV1 and TRPA1 are cation channels that play key roles in inflammatory signaling
pathways. They are co-expressed on airway C-fibers, where they exert synergistic effects on …