One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Nonalcoholic steatohepatitis (NASH), a chronic liver disease without an approved therapy, is
associated with lipotoxicity and insulin resistance and is a major cause of cirrhosis and …

Cancer progression is a highly balanced process and is maintained by a sequence of finely
tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that …

Activation of ferroptosis, a recently described mechanism of regulated cell death,
dramatically inhibits growth of ovarian cancer cells. Given the importance of lipid metabolism …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

The mechanisms by which the early-life microbiota protects against environmental factors
that promote childhood obesity remain largely unknown. Using a mouse model in which …

Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome.
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …