To execute the intricate process of development, cells coordinate across tissues and organs
to determine where each cell divides and differentiates. This coordination requires complex …

Decoding how tissue properties emerge across multiple spatial and temporal scales from
the integration of local signals is a grand challenge in quantitative biology. For example, the …

The presence of a wound triggers surrounding cells to initiate repair mechanisms, but it is
not clear how cells initially detect wounds. In epithelial cells, the earliest known wound …

While calcium signaling in excitable cells, such as muscle or neurons, is extensively
characterized, calcium signaling in epithelial tissues is little understood. Specifically, the …

The robust specification of organ development depends on coordinated cell-cell
communication. This process requires signal integration among multiple pathways, relying …

Epithelial wound healing is an evolutionarily conserved process that requires coordination
across a field of cells. Studies in many organisms have shown that cytosolic calcium levels …

Highlights•Drosophila imaginal discs are capable of regeneration after damage.•Genetic
tools enable specific regions of imaginal discs to be ablated in situ.•Reactive oxygen …

Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an
abnormal number of chromosomes, a condition that occurs frequently in cancer cells. Cells …

One of the main topics in regeneration biology is the nature of the early signals that trigger
the damage response. Recent advances in Drosophila point to the MAP3 kinase Ask1 as a …

Mechanical forces are critical but poorly understood inputs for organogenesis and wound
healing. Calcium ions (Ca 2+) are critical second messengers in cells for integrating …