Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily
located in peripheral circulation and lymphoid tissues. They kill virally infected and …

Natural killer (NK) cells are attractive within adoptive transfer settings in cancer
immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced …

Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune
effector cells. Although most studies have evaluated CAR expression in T cells, here we …

T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the
field of cellular therapy for cancer. Despite its success, this strategy has some recognised …

Natural killer (NK) cells represent an attractive lymphocyte population for cancer
immunotherapy due to their ability to lyse tumor targets without prior sensitization and …

Simple Summary Induced pluripotent stem cells (iPSCs) that can be genetically engineered
and differentiated into different types of immune cells, providing an unlimited resource for …

Natural killer (NK) cells play an essential role in the fight against tumor development. Over
the last years, the progress made in the NK-cell biology field and in deciphering how NK-cell …

Anti-tumor mAbs are the most widely used and characterized cancer immunotherapy.
Despite having a significant impact on some malignancies, most cancer patients respond …

The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer
(NK) lymphocytes opens novel possibilities for developmental studies of immune cells and …

Mouse and human pluripotent stem cells have been widely used to study the development
of the hematopoietic and immune systems. Although not all cells can be derived with the …