Microglial regional heterogeneity and its role in the brain
YL Tan, Y Yuan, L Tian - Molecular psychiatry, 2020 - nature.com
Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …
heterogeneity across different regions in the mammalian central nervous system (CNS) …
Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response
S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
Bidirectional microglia–neuron communication in health and disease
Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
Plasticity of microglia
Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …
during embryogenesis. The nervous tissue environment instigates the phenotypic …
Neuron–glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage
GK Sheridan, KJ Murphy - Open biology, 2013 - royalsocietypublishing.org
An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …
communication between neurons and neighbouring glial cells. To this end, the brain has …
Fractalkine regulation of microglial physiology and consequences on the brain and behavior
Neural circuits are constantly monitored and supported by the surrounding microglial cells,
using finely tuned mechanisms which include both direct contact and release of soluble …
using finely tuned mechanisms which include both direct contact and release of soluble …
Microglia, seen from the CX3CR1 angle
Microglial cells in brain and spinal cord are characterized by high expression of the
chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane …
chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane …
Function and dysfunction of microglia during brain development: consequences for synapses and neural circuits
RC Paolicelli, MT Ferretti - Frontiers in Synaptic Neuroscience, 2017 - frontiersin.org
Many diverse factors, ranging from stress to infections, can perturb brain homeostasis and
alter the physiological activity of microglia, the immune cells of the central nervous system …
alter the physiological activity of microglia, the immune cells of the central nervous system …
In vivo structure/function and expression analysis of the CX3C chemokine fractalkine
The CX3C chemokine family is composed of only one member, CX3CL1, also known as
fractalkine, which in mice is the sole ligand of the G protein-coupled, 7-transmembrane …
fractalkine, which in mice is the sole ligand of the G protein-coupled, 7-transmembrane …
The role of glia in the spinal cord in neuropathic and inflammatory pain
EA Old, AK Clark, M Malcangio - Pain control, 2015 - Springer
Chronic pain, both inflammatory and neuropathic, is a debilitating condition in which the
pain experience persists after the painful stimulus has resolved. The efficacy of current …
pain experience persists after the painful stimulus has resolved. The efficacy of current …