I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Contributing Authors Isam Alobid, MD, PhD1, Nithin D. Adappa, MD2, Henry P. Barham,
MD3, Thiago Bezerra, MD4, Nadieska Caballero, MD5, Eugene G. Chang, MD6, Gaurav …

Abstract Purpose of Review The objective of this article is to provide an updated review of
the economic burden of chronic rhinosinusitis (CRS) and discuss how both medical and …

Objective Both endoscopic sinus surgery (ESS) and biologic therapies have shown
effectiveness for medically‐refractory chronic rhinosinusitis with nasal polyps (CRSwNP) …

Background There is a striking lack of long‐term, prospective outcomes data for endoscopic
sinus surgery (ESS) in chronic rhinosinusitis (CRS) using validated instruments. Our primary …

The development of biologics targeting various aspects of type 2 inflammation for the
treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) will provide clinicians with …

Background The currently accepted treatment paradigm of treating chronic rhinosinusitis
(CRS) first with appropriate medical therapy (AMT) and then with surgery if patients are …

Objective To identify the need for cost-effectiveness analysis of biologic therapies in the
treatment of chronic rhinosinusitis (CRS). Data Sources Clinical trials of monoclonal …

Objective To evaluate the cost‐effectiveness of endoscopic sinus surgery (ESS) compared
to medical therapy for patients with chronic rhinosinusitis (CRS) with and without nasal …

Aspirin-exacerbated respiratory disease (AERD) patients with CRSwNP suffer from reduced
quality of life, reduced economic productivity, and higher risk of depression and sleep …