Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta

A Olmos-Ortiz, P Flores-Espinosa, L Díaz… - International Journal of …, 2021 - mdpi.com
Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

Vascular endothelial growth factor and its receptors regulation in gestational diabetes mellitus and eclampsia

A Bolatai, Y He, N Wu - Journal of Translational Medicine, 2022 - Springer
Background An imbalance in the expression of vascular endothelial growth factor (VEGF)
and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of …

Maternal PUFAs, placental epigenetics, and their relevance to fetal growth and brain development

S Basak, AK Duttaroy - Reproductive Sciences, 2023 - Springer
Dietary polyunsaturated fatty acids (PUFAs), especially omega-3 (n-3) and n-6 long-chain
(LC) PUFAs, are indispensable for the fetus' brain supplied by the placenta. Despite being …

Placental diabesity: placental VEGF and CD31 expression according to pregestational BMI and gestational weight gain in women with gestational diabetes

A Sirico, ED Rossi, VA Degennaro, V Arena… - Archives of Gynecology …, 2023 - Springer
Purpose The aim of this study is to investigate the placental expression of VEGF and CD31
in pregnancies complicated by gestational diabetes (GDM) and the influence of …

Gestational diabetes mellitus and energy-dense diet: what is the role of the insulin/IGF axis?

I Martín-Estal, F Castorena-Torres - Frontiers in Endocrinology, 2022 - frontiersin.org
Gestational diabetes mellitus (GDM), is one of the most important pregnancy complications
affecting approximately 15% of pregnant women. It is related to several gestational adverse …

Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus

AM Nuzzo, D Giuffrida, L Moretti, P Re, G Grassi… - Scientific Reports, 2021 - nature.com
Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by
endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a …

Placental secretome characterization identifies candidates for pregnancy complications

T Napso, X Zhao, MI Lligoña, I Sandovici… - Communications …, 2021 - nature.com
Alterations in maternal physiological adaptation during pregnancy lead to complications,
including abnormal birthweight and gestational diabetes. Maternal adaptations are driven by …

Preeclampsia and increased permeability over the blood–brain barrier: A role of vascular endothelial growth receptor 2

L Bergman, J Acurio, J Leon, E Gatu… - American journal of …, 2021 - academic.oup.com
BACKGROUND Cerebral complications in preeclampsia are leading causes of maternal
mortality worldwide but pathophysiology is largely unknown and a challenge to study. Using …

Implications of pregnancy on cardiometabolic disease risk: preeclampsia and gestational diabetes

M Elgazzaz, PC Woodham, J Maher… - American Journal of …, 2024 - journals.physiology.org
Cardiometabolic disorders, such as obesity, insulin resistance, and hypertension, prior to
and within pregnancy are increasing in prevalence worldwide. Pregnancy-associated …

The impact of coexisting gestational diabetes mellitus on the course of preeclampsia

K Pankiewicz, E Szczerba, A Fijałkowska… - Journal of Clinical …, 2022 - mdpi.com
A strict correlation between gestational diabetes mellitus (GDM) and preeclampsia (PE) has
been shown in previous studies. This case-control observational study evaluates the …