Insulin-like 3 peptide (INSL3) is a member of the insulin-like peptide superfamily and is the
only known physiological ligand of relaxin family peptide receptor 2 (RXFP2), a G protein …

Elephant testicles do not descend, with implications for sperm production being hot enough
to compromise germline DNA replication/repair. Uniquely, elephants also possess 20 copies …

Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms
remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to …

Abstract Comprising more than 1,400 species, bats possess adaptations unique among
mammals including powered flight, unexpected longevity, and extraordinary immunity. Some …

Vampire bats are the only mammals that feed exclusively on blood. To uncover genomic
changes associated with this dietary adaptation, we generated a haplotype-resolved …

Background Multiple alignments of mammalian genomes have been the basis of many
comparative genomic studies aiming at annotating genes, detecting regions under …

Toll-like receptors (TLRs) play an important role for the innate immune system by detecting
pathogen-associated molecular patterns. TLR5 encodes the major extracellular receptor for …

The repeated evolution of dietary specialization represents a hallmark of mammalian
ecology. To detect genomic changes that are associated with dietary adaptations, we …

Integer linear programming (ILP) is a versatile modeling and optimization technique that is
increasingly used in non-traditional ways in biology, with the potential to transform biological …

Apart from glucose, fatty acid-derived ketone bodies provide metabolic energy for the brain
during fasting and neonatal development. We investigated the evolution of HMGCS2, the …