The prominent role of CD44 in tumor cell signaling together with its establishment as a
cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC …

Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and
lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role …

Human head and neck squamous cell carcinoma (HNSCC) is a highly malignant cancer
associated with major morbidity and mortality. In this study, we determined that human …

Brain tumors can arise following deregulation of signaling pathways normally activated
during brain development and may derive from neural stem cells. Given the requirement for …

In this study, cancer cells were isolated from tumor specimens of nine glioblastoma patients.
Glioblastoma cells, cultured under suitable culture conditions, displayed markers typical of …

Background OCT 4, SOX 2, and NANOG are major transcription factors related to stem cell
self‐renewal and differentiation. The aim of this study was to examine the association of …

Background Breast cancer stem cells (BCSCs) can be enriched by culturing of cells in non-
adherent non-differentiating conditions. However, culturing mammospheres from primary …

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and
non-neoplastic cells that include both native and recruited cells. There is extensive diversity …

Cancer stem cells (CSCs) in glioblastoma multiforme (GBM) are radioresistant and
chemoresistant, which eventually results in tumor recurrence. Targeting CSCs for treatment …

Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a
genotypically and phenotypically heterogeneous population of neoplastic cells types. High …