Objective (s): 5-fluorouracil-induced (5-FU), an anticarcinogenic agent, is reported to have
side-effects that include hepatotoxicity and nephrotoxicity. The study objective was to …

Background: The application of MTX as a chemotherapy agent and immune system
suppressant has various side effects. Crocin, a xanthine derivative plant, has many …

Background: The prevention of nephrotoxicity caused by 5-fluorouracil (5-FU) can improve
patients' adherence to treatment. Aim and Objective: This study assessed the ability of …

Saffron, the stigma of Crocus sativus L., has a long history for being used in food industry
(flavoring and aromatic agent), in textile industries (dyes), and for therapeutic and medicinal …

Background: Acetaminophen (APAP) is a common analgesic and antipyretic medicine that
can lead to acute liver injury at high doses. Crocin, a Crocus sativus' ingredient, has potent …

Alpha Lipoic Acid is an antioxidant capable of inhibiting xenobiotic-induced liver toxicity as
reported in adriamycin-induced hepatotoxicity in rats. The present research was designed to …

The manifestation of acute hepatotoxicity caused by 5-fluorouracil could be characterized by
asymptomatic elevations of liver enzymes, hepatic steatosis and fuminant hepatitis. Natural …

The goal of the study is to examine the potentially harmful histopathological and biochemical
effects of 5-Fluorouracil (5-FU) on the liver and kidney. Thirty rats were divided into two …

The present study was designed to compare the side effects of Cisplatin and 5-Fluorouracil
with that of Aloe perryi leaves gel extracts. Twenty female albino rats (100–110 g) were used …

Background: Hepatotoxicity is an adverse complication in 5-Fluorouracil cancer treatment.
Inflammation, oxidative stress, apoptosis and DNA damage are essential in the …