Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …

Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle
inotropic reserve related to increased vascular afterload, arterial-ventricular load …

Autonomic dysfunction is very common in patients with dementia, and its presence might
also help in differential diagnosis among dementia subtypes. Various central nervous …

Progressive aging induces several structural and functional alterations in the cardiovascular
system, among whom particularly important are a reduced number of myocardial cells and …

The adrenergic system plays a central role in stress signaling and stress is often associated
with increased production of ROS. However, ROS overproduction generates oxidative …

Exercise training (ET) is strongly recommended in patients with chronic stable heart failure
(HF). Moderate-intensity aerobic continuous ET is the best established training modality in …

Background Aerobic exercise training is associated with beneficial ventricular remodeling
and an improvement in cardiac biomarkers in chronic stable heart failure. High‐intensity …

In heart failure (HF), exercise has been shown to modulate cardiac sympathetic
hyperactivation which is one of the earliest features of neurohormonal derangement in this …

Heart failure (HF) causes a tremendous burden on the worldwide healthcare system,
affecting> 23 million people. There are many cardiovascular disorders that contribute to the …

Introduction: G protein-coupled receptor (GPCR) kinase-2 (GRK2) is a regulator of GPCRs,
in particular β-adrenergic receptors (ARs), and as demonstrated by decades of investigation …