Toxin–antitoxin systems: biology, identification, and application

SJ Unterholzner, B Poppenberger… - Mobile genetic …, 2013 - Taylor & Francis
Toxin–antitoxin (TA) systems are small genetic elements composed of a toxin gene and its
cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are …

[HTML][HTML] Bacterial toxin-antitoxin modules: classification, functions, and association with persistence

G Singh, M Yadav, C Ghosh, JS Rathore - Current Research in Microbial …, 2021 - Elsevier
Toxin-antitoxin (TA) modules are ubiquitous gene loci among bacteria and are comprised of
a toxin part and its cognate antitoxin part. Under normal physiological conditions, antitoxin …

PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides

P Thevenet, Y Shen, J Maupetit, F Guyon… - Nucleic acids …, 2012 - academic.oup.com
In the context of the renewed interest of peptides as therapeutics, it is important to have an
on-line resource for 3D structure prediction of peptides with well-defined structures in …

Rosetta FlexPepDock web server—high resolution modeling of peptide–protein interactions

N London, B Raveh, E Cohen, G Fathi… - Nucleic acids …, 2011 - academic.oup.com
Peptide–protein interactions are among the most prevalent and important interactions in the
cell, but a large fraction of those interactions lack detailed structural characterization. The …

Toxins-antitoxins: diversity, evolution and function

F Hayes, L Van Melderen - Critical reviews in biochemistry and …, 2011 - Taylor & Francis
Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …

Toxin–antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate

CF Schuster, R Bertram - FEMS microbiology letters, 2013 - academic.oup.com
Toxin–antitoxin (TA) systems are small genetic elements found on plasmids or
chromosomes of countless bacteria, archaea, and possibly also unicellular fungi. Under …

The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

F Sterpone, S Melchionna, P Tuffery… - Chemical Society …, 2014 - pubs.rsc.org
The OPEP coarse-grained protein model has been applied to a wide range of applications
since its first release 15 years ago. The model, which combines energetic and structural …

Structure, biology, and therapeutic application of toxin–antitoxin systems in pathogenic bacteria

KY Lee, BJ Lee - Toxins, 2016 - mdpi.com
Bacterial toxin–antitoxin (TA) systems have received increasing attention for their diverse
identities, structures, and functional implications in cell cycle arrest and survival against …

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

JJ Williams, PJ Hergenrother - Trends in microbiology, 2012 - cell.com
Toxin–antitoxin (TA) systems are unique modules that effect plasmid stabilization via post-
segregational killing of the bacterial host. The genes encoding TA systems also exist on …

Peptide docking and structure-based characterization of peptide binding: from knowledge to know-how

N London, B Raveh, O Schueler-Furman - Current opinion in structural …, 2013 - Elsevier
Highlights•Accrual of peptide–protein complex structures allowed their detailed
characterization.•This has lead to rapid progress in peptide docking, based on diverse …