Pharmacodynamic drug–drug interactions
Pharmacodynamic drug–drug interactions (DDI s) occur when the pharmacological effect of
one drug is altered by that of another drug in a combination regimen. DDI s often are …
one drug is altered by that of another drug in a combination regimen. DDI s often are …
[HTML][HTML] Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of …
T Tuntland, B Ethell, T Kosaka, F Blasco… - Frontiers in …, 2014 - frontiersin.org
Characterizing the relationship between the pharmacokinetics (PK, concentration vs. time)
and pharmacodynamics (PD, effect vs. time) is an important tool in the discovery and …
and pharmacodynamics (PD, effect vs. time) is an important tool in the discovery and …
[PDF][PDF] Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms
PK Sorger, SRB Allerheiligen… - An NIH white …, 2011 - customsitesmedia.usc.edu
Background: This white paper arises from two workshops held at the NIH in 2008 and late
2010 with participation from academia, industry and government (http://meetings. nigms. nih …
2010 with participation from academia, industry and government (http://meetings. nigms. nih …
Pharmacokinetic and pharmacodynamic modeling of siRNA therapeutics–a minireview
JY Jeon, VS Ayyar, A Mitra - Pharmaceutical research, 2022 - Springer
The approval of four small interfering RNA (siRNA) products in the past few years has
demonstrated unequivocally the therapeutic potential of this novel modality. Three such …
demonstrated unequivocally the therapeutic potential of this novel modality. Three such …
[HTML][HTML] Extensions to the visual predictive check to facilitate model performance evaluation
Abstract The Visual Predictive Check (VPC) is a valuable and supportive instrument for
evaluating model performance. However in its most commonly applied form, the method …
evaluating model performance. However in its most commonly applied form, the method …
Merging systems biology with pharmacodynamics
R Iyengar, S Zhao, SW Chung, DE Mager… - Science translational …, 2012 - science.org
The emerging discipline of systems pharmacology aims to combine analysis and
computational modeling of cellular regulatory networks with quantitative pharmacology …
computational modeling of cellular regulatory networks with quantitative pharmacology …
Translational pharmacokinetic/pharmacodynamic model for mRNA-3927, an investigational therapeutic for the treatment of propionic acidemia
Propionic acidemia (PA) is an ultrarare disorder caused by deficiency of the mitochondrial
enzyme, propionyl-CoA carboxylase (PCC), composed of PCCA and PCCB subunits. An …
enzyme, propionyl-CoA carboxylase (PCC), composed of PCCA and PCCB subunits. An …
Minimal physiologically based pharmacokinetic-pharmacodynamic (mPBPK-PD) model of N-Acetylgalactosamine–Conjugated small interfering RNA disposition and …
Conjugation of small interfering RNA (siRNA) to tris N-acetylgalactosamine [(GalNAc) 3] can
enable highly selective, potent, and durable knockdown of targeted proteins in the liver …
enable highly selective, potent, and durable knockdown of targeted proteins in the liver …
Scaling pharmacodynamics from in vitro and preclinical animal studies to humans
An important feature of mechanism-based pharmacokinetic/pharmacodynamic (PK/PD)
models is the identification of drug-and system-specific factors that determine the intensity …
models is the identification of drug-and system-specific factors that determine the intensity …
[HTML][HTML] Application of pharmacokinetic and pharmacodynamic analysis to the development of liposomal formulations for oncology
S Ait-Oudhia, DE Mager, RM Straubinger - Pharmaceutics, 2014 - mdpi.com
Liposomal formulations of anticancer agents have been developed to prolong drug
circulating lifetime, enhance anti-tumor efficacy by increasing tumor drug deposition, and …
circulating lifetime, enhance anti-tumor efficacy by increasing tumor drug deposition, and …