[HTML][HTML] Establishing neuronal diversity in the spinal cord: a time and a place
The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …
arranged in characteristic positions. During development, these different types of neurons …
Motor neurons and the generation of spinal motor neuron diversity
N Stifani - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
[PDF][PDF] Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord
The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …
tube determines the identity of neural progenitors and the function and physiology of the …
Modeling ALS with motor neurons derived from human induced pluripotent stem cells
Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …
SOX2 functions to maintain neural progenitor identity
V Graham, J Khudyakov, P Ellis, L Pevny - Neuron, 2003 - cell.com
Neural progenitors of the vertebrate CNS are defined by generic cellular characteristics,
including their pseudoepithelial morphology and their ability to divide and differentiate …
including their pseudoepithelial morphology and their ability to divide and differentiate …
[HTML][HTML] Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
Distinct classes of motor neurons and ventral interneurons are generated by the graded
signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing …
signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing …
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
CE Henderson, HS Phillips, RA Pollock, AM Davies… - Science, 1994 - science.org
For survival, embryonic motoneurons in vertebrates depend on as yet undefined
neurotrophic factors present in the limb bud. Members of the neurotrophin family are …
neurotrophic factors present in the limb bud. Members of the neurotrophin family are …
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
F Guillemot, LC Lo, JE Johnson, A Auerbach… - Cell, 1993 - cell.com
The mouse Mash-7 gene, like its Drosophila homologs of the achaete-scute complex (AS-
C), encodes a transcription factor expressed in neural precursors. We created a null allele of …
C), encodes a transcription factor expressed in neural precursors. We created a null allele of …
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
MK Cooper, JA Porter, KE Young, PA Beachy - Science, 1998 - science.org
Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for
more than 30 years as potent teratogens capable of inducing cyclopia and other birth …
more than 30 years as potent teratogens capable of inducing cyclopia and other birth …
IPF1, a homeodomain‐containing transactivator of the insulin gene.
H Ohlsson, K Karlsson, T Edlund - The EMBO journal, 1993 - embopress.org
We describe the cloning of insulin promoter factor 1 (IPF1), a homeodomain protein which in
the adult mouse pancreas is selectively expressed in the beta‐cells and which binds to and …
the adult mouse pancreas is selectively expressed in the beta‐cells and which binds to and …