The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …

Neural progenitors of the vertebrate CNS are defined by generic cellular characteristics,
including their pseudoepithelial morphology and their ability to divide and differentiate …

Distinct classes of motor neurons and ventral interneurons are generated by the graded
signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing …

For survival, embryonic motoneurons in vertebrates depend on as yet undefined
neurotrophic factors present in the limb bud. Members of the neurotrophin family are …

The mouse Mash-7 gene, like its Drosophila homologs of the achaete-scute complex (AS-
C), encodes a transcription factor expressed in neural precursors. We created a null allele of …

Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for
more than 30 years as potent teratogens capable of inducing cyclopia and other birth …

We describe the cloning of insulin promoter factor 1 (IPF1), a homeodomain protein which in
the adult mouse pancreas is selectively expressed in the beta‐cells and which binds to and …