Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

Abstract With only 1.3− 4.3% in total hepatic CYP content, human CYP2D6 can metabolize
more than 160 drugs. It is a highly polymorphic enzyme and subject to marked inhibition by …

Introduction: Understanding the factors causing inter-and intra-individual differences in drug
metabolism potencies is required for the practice of personalized or precision medicine, as …

MicroRNAs (miRNAs) that regulate the cytochrome P-450 isoforms involved in
acetaminophen (APAP) toxicity were examined in HepaRG cells treated with APAP (20 mM) …

Compared to rifampicin (600 mg/day), standard doses of rifabutin (300 mg/day) have a lower
risk of drug–drug interactions due to induction of cytochrome P450 3A4 (CYP3A4) or P …

We previously demonstrated a distinct hepatic microRNA (miRNA) signature (down‐
regulation of miRNA‐23a,‐150,‐200b,‐503, and‐663 and up‐regulation of miRNA‐20a) is …

Membrane drug transporters contribute to the disposition of many drugs. In human liver,
drug transport is controlled by two main superfamilies of transporters, the solute carrier …

The pregnane X receptor (PXR, encoded by the NR1I2 gene) is a ligand-regulated
transcription factor originally described as a master regulator of xenobiotic detoxification …

Developmental changes in the liver can significantly impact drug disposition. Due to the
emergence of microRNAs (miRNAs) as important regulators of drug disposition gene …

Inter-individual variation in gene regulatory elements is hypothesized to play a causative
role in adverse drug reactions and reduced drug activity. However, relatively little is known …