Cardiomyocyte maturation: new phase in development
Y Guo, WT Pu - Circulation research, 2020 - Am Heart Assoc
Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
Novel strategies to address the challenges in top-down proteomics
JA Melby, DS Roberts, EJ Larson… - Journal of the …, 2021 - ACS Publications
Top-down mass spectrometry (MS)-based proteomics is a powerful technology for
comprehensively characterizing proteoforms to decipher post-translational modifications …
comprehensively characterizing proteoforms to decipher post-translational modifications …
A high-stringency blueprint of the human proteome
Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …
(HPP) in 2010, creating an international framework for global collaboration, data sharing …
A patterned human primitive heart organoid model generated by pluripotent stem cell self-organization
Pluripotent stem cell-derived organoids can recapitulate significant features of organ
development in vitro. We hypothesized that creating human heart organoids by mimicking …
development in vitro. We hypothesized that creating human heart organoids by mimicking …
Top-down proteomics: challenges, innovations, and applications in basic and clinical research
KA Brown, JA Melby, DS Roberts… - Expert review of proteomics, 2020 - Taylor & Francis
Introduction-A better understanding of the underlying molecular mechanism of diseases is
critical for developing more effective diagnostic tools and therapeutics toward precision …
critical for developing more effective diagnostic tools and therapeutics toward precision …
Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics
Hypertrophic cardiomyopathy (HCM) is the most common heritable heart disease. Although
the genetic cause of HCM has been linked to mutations in genes encoding sarcomeric …
the genetic cause of HCM has been linked to mutations in genes encoding sarcomeric …
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on …
J van der Velden, FW Asselbergs… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …
research to improve diagnostics, and to discover and test novel preventive and curative …
High-throughput quantitative top-down proteomics
KA Cupp-Sutton, S Wu - Molecular omics, 2020 - pubs.rsc.org
Top-down mass spectrometry (MS) analyzes intact proteins at the proteoform level, which
allows researchers to better understand the functions of protein modifications. Recently, top …
allows researchers to better understand the functions of protein modifications. Recently, top …
Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology
WJ de Lange, ET Farrell, CR Kreitzer… - American Journal …, 2021 - journals.physiology.org
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) may
provide an important bridge between animal models and the intact human myocardium …
provide an important bridge between animal models and the intact human myocardium …
[HTML][HTML] RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis
Abstract Arginine–serine (RS) domain (s) in splicing factors are critical for protein–protein
interaction in pre‐mRNA splicing. Phosphorylation of RS domain is important for splicing …
interaction in pre‐mRNA splicing. Phosphorylation of RS domain is important for splicing …